For the first time, a human heart transplant … to help scientists find ways to treat heart disorders

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Scientists in the United States have developed the first working small models of the human heart to help identify heart disorders in the laboratory, and human heart organelles have been created. (hHOs), Which contains working chambers and vascular tissue, using stem cells to mimic “n uts And screws “about how the heart of a fetus grows in the womb .

Started at The tiny, spherical hearts, which grew to about 0.04 inch (1 mm) in diameter after just 15 days, were only six days old..

Laboratory miniature human heart models will help scientists better understand how defects such as congenital heart disease, which affect 1 percent of all live births, develop..

Using our cardiomyopathy, we can study the origin of congenital heart disease and find ways to stop it, said Aitor Aguirre, assistant professor of biomedical engineering at Michigan State University. These little hearts are incredibly powerful models for studying all types of heart disorders with a degree of accuracy never seen before. .

I showed at Very similar to the hearts of a human fetus, in terms of morphology – in terms of structure – and complexity of cell type and have “ complex and interconnected inner chambers ”.

One of the main issues facing the study of fetal heart growth and congenital heart defects is access to the developing heart. Previously, researchers had limited themselves to using mammalian models and the remains of donated embryos..

Aguirre said: “Now we can have the best of both worlds, an accurate human model for studying these diseases. A small human heart without using embryonic material or violating ethical principles.”“.

The team used the pluripotent stem cells (iPSCs) – These are adult cells taken from a patient – to stimulate fetal-like heart growth in a dish.

“This process allows stem cells to develop, essentially as in an embryo, into the different types of cells and structures found in the heart,” Aguirre said. “The team says their method is scalable and can be replicated in other laboratories..

In addition to congenital heart disease, the HMOs can help study the cardiac toxicity caused by chemotherapy and the effect of diabetes during pregnancy on the developing heart of the fetus..

However, the hHO “ Far from perfect ” compared to the human heart, and future research at Michigan State University will aim to improve the models.

“Organelles are small models of the fetus’s heart with representative functional and structural features, however, they are not as perfect as the human heart yet. This is something we are working on,” said Yonatan Israel, a graduate student in Aguirre lab and first author of the study..

The stem cells used in the operation were obtained from consenting adults and thus free of ethical concerns.

The study was funded by grants from the American Heart Association and the National Institutes of Health in the United States, where heart disease is the leading cause of death..

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