Smell cells are the main entry point for the body to be infected with the Coronavirus


A new study revealed why some Corona virus patients lose their sense of smell, and the researchers found that the nasal cells that help us detect odors are the main entrance to the Corona virus, as the part of the cells that the virus sticks to and infects it spreads up to 700 times in the lining of the upper part of the The nose compared to the lining of the rest of the nose or trachea.

According to the Daily Mail, these support cells play a vital role in the function and development of odor-sensing cells – and may be damaged when the pathogen attacks them.

The research team, from Johns Hopkins University, said the results could lead to drugs or other treatments that target these cells until a vaccine is developed.

“Loss of smell is associated with Covid 19, generally in the absence of other nasal symptoms,” said Dr. Andrew Lynn, professor of otolaryngology at Johns Hopkins University School of Medicine and lead author of the study.

“Our research may advance the search for a specific cause of how and why this happens, and where we can better target some treatments,” he added.

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Healthcare workers began drawing attention to several new symptoms, such as a loss of the sense of taste and smell, in March.

In the same month, the American Academy of Otolaryngology invited the Centers for Disease Control and Prevention to add loss of smell – the inability to smell – to the list of possible signs of coronavirus.

However, it is not clear why some coronavirus patients develop these symptoms.

For the study, published in the European Respiratory Journal, the team looked at nasal tissue samples from 19 adult men and women with chronic sinusitis, an infection of the nasal tissue.

They also examined tracheal tissue samples from seven people who had undergone surgery for an abnormal narrowing of the windpipe.

These samples were compared to four people who underwent nasal surgery for reasons other than sinusitis.

Children have not been screened because they have low levels of ACE2 In the cells lining their noses, the scientists specifically searched for the ACE-2 receptor.ACE2), Which is the receptor that the virus uses to enter and infect human cells.

They found high levels of ACE2 Between the nasal cells are in an area called the olfactory nerve epithelium, where the odor-sensing neurons are located.

Cells in the olfactory nerve epithelium have between 200 and 700 times more receptors ACE2 Compared to other samples from the nose and trachea.

The researchers said that the results could lead to the development of drugs, or even a topical cream, to be placed inside the nostrils that target these cells and cut off transmission.

Because odor-sensing cells contain the highest levels of the enzyme ACE2 , The team believes this is the reason some patients are missing COVID-19 Sense of smell.

The authors said that the general public does not only need to wear masks but wear them properly, so that they cover the nose and mouth to prevent the virus.


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