More dangerous than the lung … a study warns of the effect of the Corona virus on the brain

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A recent study showed that the headaches, confusion and delirium that some Corona Covid-19 patients suffer from may be a result of the Corona virus, which invades the brain directly.
According to the research paper led by immunologist Akiko Iwasaki, the Coronavirus is able to reproduce inside the brain, and its presence deprives brain cells close to oxygen.

The techniques used in the study were praised by S. Andrew Josephson, chair of the Department of Neurology at the University of California, who said, “Understanding whether there is direct viral involvement of the brain is very important.”

Incredible opportunity “timesofindia”، It wouldn’t be totally shocking if SARS-CoV-2 was able to penetrate the blood-brain barrier, which is the structure that surrounds blood vessels in the brain and tries to block foreign substances.

But doctors have so far believed that the neurological effects observed in about half of patients could instead be the result of an abnormal immune response known as a cytokine storm that causes encephalitis – rather than directly invading the virus.

The team in the study found in brain organelles that the SARS-CoV-2 virus is able to infect neurons and then hijack the nerve cell mechanism to make copies of itself.

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The team noted the affected cells in turn promoted the death of the surrounding cells by suffocating the oxygen supply.

One of the main arguments against the direct brain invasion theory has been that the brain lacks high levels of a protein called ACE2 that the coronavirus attaches to, and which is found in abundance in other organs such as the lungs.

But the team found that the organelles contained enough ACE2 to facilitate the entry of the virus, and that the proteins were also present in the brain tissues of the deceased patients.

They also performed a spinal tap on a hospitalized Coronavirus patient suffering from delirium and found that the individual had equivalent antibodies to the virus in the spinal fluid – further evidence in favor of their theory.
Those injured in their lungs showed some signs of lung infection, while those in the brain lost weight quickly, indicating the possibility of a higher death rate when the Coronavirus enters this organ.
They also examined the brains of three patients who had died from serious complications linked to the Covid-19 Coronavirus, and found evidence of the virus in all to varying degrees.

Interestingly, the affected areas did not show signs of penetration of immune cells, such as T cells, which rush to sites of other viruses such as Zika or herpes to kill the infected cells.

This may indicate that the increased immune response known as a cytokine storm, which is responsible for much of the observed damage in the lungs of patients with COVID-19, may not be the main cause of the neurological symptoms.

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