Pandemic infected a virus COVID-19 More than 40 million people around the world, and despite the high death rate among hospitalized patients, many of them have survived, although little is known about the medium to long-term effects of the disease. COVID-19 After discharge from the hospital.
Although predominantly respiratory disease, emerging data indicate that multi-organ infection is common, especially in moderate to severe infections, and a new study published on the preprint website describes medRxiv *, The consequences of illness in the months following the recovery.
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Multi-organ damage from COVID-19
Corona virus COVID-19 It is mostly a respiratory disease or lung disease, but with data coming in from around the world, it appears that many organs are affected by the virus, and this is more when the infection is severe or moderate, it appears that the most sensitive organs are the brain, heart, digestive system and kidneys.
The occurrence of infection is a defect that occurs in the regulation of the immune response by the virus, according to a website report. theconversation“, Which leads to severe inflammation, endothelial injury, blood clotting abnormalities, and the resulting damage. The results depend on the extent of infection and inflammation and the health status of the individual before the injury.”
Persistent symptoms and signs of organ damage
The researchers found, that persistent shortness of breath was present in two-thirds of the patients, with fatigue in more than half of the patients, and a CT scan of the chest revealed abnormalities in the lungs in 60% of the patients, while a quarter to a half showed changes in the heart and kidneys, respectively, while it showed Ten liver injury.
Other observed changes included abnormalities in different parts of the brain, while impaired cognitive performance in both the executive and visual-spatial areas, where damage to multiple organs during the convalescence is associated with inflammatory signs and acute disease severity, providing the last prognostic value.
Moderate to severe anxiety, and depression has been reported by more than a third of patients, mostly due to: Persistent shortness of breath While they tested negative for the virus.
Overall, they reported a significant decrease in the quality of life they enjoyed, and a large proportion of this impairment was due to loss of physical condition, persistent shortness of breath, and exhaustion, which prevented activities of daily living from functioning as usual.
The report also mentioned that up to a third of patients COVID-19 Those who need hospital treatment suffer from acute heart muscle injury, which predicts a higher risk of death
In the current study, only a quarter of patients showed cardiac inflammation associated with inflammatory serum markers, and this may require further work on the comparability of different studies that use different reference ranges, methods and have different patient groups.
Liver injury may be in survivors of COVID-19 It is also caused by hyperinflammation, abnormalities of liver metabolism due to hypoxia, venous thrombosis, and the effects of drugs used to treat infections.