Spain took the lead in the first half by Alvaro Morata, before conceding a goal that cost it two points by Anastasios Pakacitas from a penalty kick.
The two teams share match points at the beginning of the qualifying campaign.
Spain failed to win a match in Granada for the first time in its history, after winning 7 previous matches played in the Andalusian city.
The match saw Spain’s coach Luis Enrique depend on Unai Simon in goalkeeping at the expense of David de Gea. Marcos Llorente also participated as a right-back.
Spain started the game quietly and did not threaten the goal until the 31st minute, when Dani Olmo fired a powerful shot, which rebounded from the crossbar.
The threat turned into reality when Morata scored the home side’s first goal in the 33rd minute, after a long pass from Kuki, which the Juventus striker received in the chest and finished brilliantly in the net.
To raise Moratas score of international goals to 19, and become the historic No. 13 scorer for La Roja national team.
At the start of the second half, Luis Enrique made a change by removing captain Sergio Ramos and replacing him with Inigo Martinez in the center of the defense.
The Spanish radio, “Cadena Ser”, stated that Ramos’ change was agreed upon in advance and that he was healthy and did not suffer from an injury.
But the results backfired, so substitute Inigo Martinez awarded a penalty after an intervention on Giorgos Masoras.
This would be the first penalty kick awarded to Spain at home in its World Cup qualifying campaign.
Pakasitas took the lead in the 57th minute, scoring successfully and equalizing the score.
Luis Enrique moved quickly and entered the young duo, Pedri and Brian Khel, in the 64th minute, instead of Olmo and Sergio Canales, to score their first appearance with La Roja.
Brian Khel became the first-ever Eibar player to represent Spain.
While Pedri became the sixth youngest player to represent Spain, aged 18 years and 120 days.
Then Luis Enrique pushed Thiago Alcantara instead of Koki, and Mikel Uiarzabal instead of Ferran Torres, without getting offensive results.
Spain stumbled on its home soil in the first round.
In the same group, Sweden defeated Georgia with a single goal at the Friends Arena.
Victor Clayson scored Sweden’s only goal in the 35th minute from the return of Zlatan Ibrahimovic.
The AC Milan veteran played his first international match since his last appearance at Euro 2016.
Ibrahimovic played from the start in the offensive line next to Real Sociedad player Alexandre Isaac, before leaving the field in the 84th minute, leaving his place to Robin Kwaison.
This group consists of 5 teams, and therefore Kosovo did not play a match in this round.
And in the fifth group, Scotland tied against Austria at Hampden Park, with two goals for each side.
Sasha Kalayzdic advanced to Austria in the 55th minute, before Grant Hanley equalized for Scotland in the 71st minute.
Then Kallajzdic returned to Austria in the 80th minute, but John Magin snatched a tie for Scotland in the 85th minute from the creation of Ryan Christie.
Moldova also tied against its guest, the Faroe Islands, with one goal for each side.
Yon Nicolasco took the lead in the ninth minute to Moldova, before the Faroe Islands equalized in the last seven minutes by Meinhard Olsen.