The research, conducted by scientists at Kyoto University and Fukui University in Japan, began with a pair of molecules called a “morphogenetic bone protein”.
These molecules are known to regulate the growth of various organs and tissues during the very early stages of Human evolutionBut the team wanted to investigate specifically how they affect tooth growth, and how these processes can be used for regenerative treatments. This led them to a gene called gene # 1 associated with growth.
Because an interaction between Gene No. 1 and the morphogenetic bone protein was discovered, scientists suspected that this could provide a pathway to interfere with dental behavior and growth.
But the problem that the study alerted to is that targeting morphogenetic bone protein activity in this way can generally affect the whole body, given the broad functions of the molecules.
The team tested the effects of several monoclonal antibodies on gene No. 1 in mice with a genetic condition characterized by tooth loss.
Scientists describe this study as the first to demonstrate how monoclonal antibody drugs can help rejuvenate teeth.
Subsequent trials with pigs and dogs have yielded equally promising results, and the team envisions that treatment will someday become an effective approach to treating non Tooth formation Genetic.