Katsu Takahashi / Kyoto University
Nature gives a person molars only once in his life. However, they rarely serve him for a lifetime. Because she is exposed to various diseases and injuries. It is not possible to grow new molars.
And the Science Advances magazine indicates that scientific achievements no longer amaze us, and the day will come when we forget dental implants, and this is what was revealed by the results of a new Japanese study conducted by scientists from the Universities of Kyoto and Fukui.
And it became clear to the researchers, that antibodies to the USAG-1 gene, stimulates tooth growth in mice with growth abnormalities (the absence of some teeth from birth). This case is also observed in 1% of the Earth’s population, where they have 28 teeth instead of 32, and there are those who have more than 32 teeth among humans.
Many factors contribute to the growth of teeth. The scientists were able to identify two main components: the morphological bone protein BMP and the Wnt signaling pathway, which was also built by proteinuria, and they contribute to the formation of many tissues and organs at different stages of the development of the fetus. Therefore, drugs that affect their activity are not common, due to the various side effects resulting from their use.
The researchers knew that suppressing USAG-1 gene activity stimulates tooth growth. And that this gene interacts with BMP and Wnt protein. So they decided to specifically influence this gene, to limit the possible negative effects of treatment.
In this study, the researchers used monoclonal antibodies that are used in treating cancer, arthritis and in developing vaccines, to target this gene. Some experiments allowed the researchers to identify one type of these antibody that suppressed the interaction of the USAG-1 gene with the BMP protein. It turned out that one injection of the drug was sufficient for the growth of the deficient tooth. The results of subsequent experiments showed that this method of treatment has the same effect on the teeth of a ferret (a type of rodent), who, like humans, first develops milky teeth, and then they are replaced by permanent teeth. Therefore, the researchers believe that the recent experiments are very important and successful.
The researchers plan to conduct new experiments on larger animals such as pigs and dogs, and if their results are positive, the day will come when it becomes easier to grow a new tooth instead of treating the affected tooth.
Source: Vesti. Ru