Yannick Ferreira Carrasco was presented to the guests very early, but Christian Tue equalized for the hosts before the expiration of a third of an hour.
Atletico Madrid raised its score to 67 points and regained the lead, but one point behind Real Madrid, who has 66 points, after their victory over Barcelona yesterday in El Clasico.
Barcelona are third with 65 points, sparking the struggle for the Spanish League title in the last 8 rounds.
This comes after Atletico Madrid was ahead of Real Madrid and Barcelona by 10 full points in the 21st round of the competition.
As for Real Betis, it raised its tally to 47 points in sixth place, and kept the points equal to the fifth Real Sociedad.
This is Atleticos seventh stumble in the last 11 rounds, during which only 4 wins were known, a draw by 5 and lost twice.
On the other hand, Diego Simeone’s complex continued to Manuel Pellegrini, as the Chilean coach had never defeated his Argentine counterpart in 6 confrontations between them.
Atletico Madrid entered the match without its most important injured players: Luis Suarez, Marcos Llorente and Thomas Lemar.
Simeone pushed the duo, Angel Martin Correa and Joao Felix in an attacking brace for a 3-5-2 formation.
While the veteran Pellegrini compensated for the absence of his scorer Borja Iglesias by pushing with Aitor Roubal and his successor captain Joaquin Sanchez.
Atletico Madrid needed just 4 minutes 33 seconds to get ahead of Carrasco, who scored the fastest goal for his team this season.
Carrasco finally scored for the first time in 2021, as his last goal came on December 9th against Salzburg in the Champions League.
The visiting team continued their attack and almost doubled the score with Saul Nijis header in the 15th minute, but veteran Claudio Bravo saved brilliantly.
The equalizer was not too late, and former Barcelona winger Teo caught him with a wonderful one-touch shot after Alex Morenos perfect cross in the 20th minute.
To raise Tios tally to 5 goals in the Spanish League this season.
The end of the half carried bad news for Simeone, injuring his young striker, Joao Felix, after a strong intervention from Algerian Issa Mandi.
The Portuguese appeared very painful, but suddenly he returned to the field with his teammates at the start of the second half.
It did not last for more than two minutes until Felix fell again, forcing Simeone to replace him with Lucas Torreira, and thus Carrasco turned into a second striker due to the few options on the bench.
Atletico lost his balance, and he received a barrage of Andalusian attacks, which began with Brazilian Emerson with a header in the 57th minute, but Jan Oblak shone and kept the result of the tie.
Simeone then tried to catch the match, putting Renan Lodi and Vitolo instead of Mario Hermoso and Hector Herrera. Joaquin left and was replaced by Juanmi with the attack of Betis.
This did not stop the homeowners’ attacks, and Ruibal could have added the second in the 74th minute, had Jose Maria Jimenez not intervened at the last moment in front of his shot.
Roebal came out immediately afterwards and was replaced by young Mexican Diego Lainez, who needed one minute to threaten Atleticos goal in his first touch when he fired a powerful shot from inside the penalty area, and Oblak miraculously saved it in the 76th minute.
Atleticos crises doubled in the 78th minute when Kiiran Trippier was injured in the back and left the field, to be replaced by Croatian Simi Versalico.
In the last moments, the cuff turned and Atletico Madrid pressed ferociously to try to cling to the league title, but he collided with a massive wall called Claudio Bravo.
The former goalkeeper for Real Sociedad, Barcelona and Manchester City, made two stunning saves against Correa in stoppage time, to prevent him from snatching full points, and spoiling good news for the two El Clasico poles.
Now, any further stumbling for Atletico Madrid, would mean losing the top of the league, which they have occupied for 19 rounds.