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Nature gives a person molars once in his life, but unfortunately it rarely serves him throughout his life, as it is exposed to various diseases and injuries, and often ends up with dislocation or filling.
The Science Advances magazine indicated that the scientific achievements no longer amaze us, and the day will come when we forget dental implants, according to what was revealed by the results of a new Japanese study conducted by scientists from the Universities of Kyoto and Fukui, according to RT Arabic.
And it became clear to the researchers that antibodies to the USAG-1 gene stimulate tooth growth in mice that suffer from growth abnormalities (the absence of some teeth since birth), and this case is also observed in 1% of the Earth’s population, where they have 28 teeth instead of 32, and there are those who have it. More than 32 ages in humans.
Many elements contribute to the growth of teeth, as scientists were able to identify two main components: the morphological bone protein BMP and the signaling pathway Wnt, which was built by protein also, as they contribute to the formation of many tissues and organs at different stages of the development of the fetus, so the drugs affecting their activity are not They are common, due to the various side effects from their use.
The researchers knew that suppressing the activity of the USAG-1 gene stimulates tooth growth, and that this gene interacts with BMP and Wnt protein, so they decided to specifically affect this gene, to reduce the potential negative effects of treatment.
In this study, the researchers used monoclonal antibodies, used in treating cancer, arthritis and in developing vaccines, to target this gene.
Some experiments allowed researchers to identify one type of these antibody that suppressed the interaction of the USAG-1 gene with the BMP protein. And it became clear to them, that a single injection of the drug is sufficient for the growth of the deficient tooth, as the results of subsequent experiments showed that this method of treatment has the same effect on the teeth of a ferret (a type of rodent), who, like humans, develops first milk teeth, and then they are replaced by teeth Permanent, so researchers believe that recent experiments are very important and successful.
The researchers plan to conduct new experiments on larger animals such as pigs and dogs, and if their results are positive, the day will come when it becomes easier to grow a new tooth instead of treating the affected tooth.
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