Mamelodi Sun Downs defeated Orlando Pirates by 3-0 in the match that brought them together in the 26th round of the South African League.
Ricardo Nascimento scored a hat-trick for Sun Downs from the penalty spot, Peter Shalolili and Lyle Lacay.
Mahjmed Sun Downs, Kermit Erasmus, left the match at half-time due to injury.
The victory brought Sun Downs to 51 points at the top of the South African League standings, one point behind second-placed Amazulu.
And the yellow team still has two postponed matches, if it wins them, it will expand the difference with Amazulu to 7 points.
Sun Downs will play Al-Ahly in the 8th round of the African Champions League.
It is the third time in a row that Al-Ahly has met Sun Downs in the quarter-finals of the African Champions League.
The first-leg match will take place in Cairo on the 14th or 15th of May, while the return match will take place in South Africa a week after the first leg.