Egyptian Mohamed El-Niny is on the bench despite the suspension of the dismissed Danny Ceballos in the first leg.
Arteta relies on the 3-4-3 method in its offensive form by recruiting Granit Chaka as the third center back, pushing Hector Bellerin as a right-back, and Bukayo Saka as the left-back.
Captain Pierre Emerick Aubameyang starts offensively alongside Martin Odegaard and Nicholas Pepe.
On the other hand, Villarreal coach Unai Emery continued to rely on the 4-3-3 method.
Emery paid French Frances Cocolin, the former Arsenal player, to replace the suspended Etienne Capoy.
Goalkeeping: Bernard Leno
Defense: Rob Holding – Pablo Marie – Granite Chaka
the middle: Hector Bellerin – Thomas Party – Emil Smith Rowe – Bukayo Saka
attack: Martin Odegaard – Pierre Emerick Aubameyang – Nicholas Pepe
Goalkeeping: Jeronimo Roy
Defense: Mario Gaspar – Raul Albiol – Pau Torres – Alfonso Pedraza
the middle: Danny Parejo – Francis Coquelin – Manu Trejros
attack: Samu Choquezi – Gerard Moreno – Paco Alcacer