Burak Yilmaz and Muhammad Zaki ليكilek scored the two goals for Lille in the two minutes: 13 and 55, respectively.
The victory returned Lille to the top of the French League with 76 points, to regain first place from Paris Saint-Germain, who beat Lance and reached the 75th point.
As for Nice, its score stopped at point 46 to occupy the ninth place.
The victory is the fourth night in the last 5 matches, after defeating Paris Saint-Germain, Metz, Lyon, and a draw with Montpellier.
Burak Yilmaz reached his 13th goal in the league this season.
To become the second most Turkish striker to score goals in one season in the French League, after Mouloud Erding.
Erding had scored 15 goals for Paris Saint-Germain in the 2009-2010 season.
Lille plays the next match against Lance, while Nice plays Brest.