“There is always such a thing as the first time in my life, and I look forward to that,” Simeone replied at a press conference held on Friday.
Although Simeone defeated Barcelona four times in 29 games, none of them were at the Camp Nou.
Atletico will visit Barcelona for their match in the 35th round of the Spanish League.
Atletico tops the league with 76 points, two points behind Real Madrid and Barcelona.
Seville comes fourth, with 70 points.
Regarding the key to winning the league title, the Argentine coach said: “The state of mind for every team is the key to winning the championship.”
“We have to harm Barcelona, and I don’t see Ronald Koeman’s absence from the bench as an advantage for us,” he added.
“We will not change the way we play and we will try to do the good things that we used to do,” he stressed.
And he added, “We are going into the match with a lot of enthusiasm and I have strong confidence in my team.”
Simeone praised Bien Oblak, the Atletico goalkeeper, saying: “He is the best goalkeeper in the world, Marc-Andre ter Stegen is doing a very good job and he is one of the best goalkeepers in the world.”
About the fate of the title, he said: “I do not want to rush to judgment.”