The Wolves team lost for the second time in a row in the league, after losing its lead to lose against Venice, returning to the championship after an absence of 19 years.
Mattia Caldara took an early lead for the hosts in the third minute, but veteran coach Jose Mourinhos men responded with a goal by Eldor Shumordov in the 43rd minute.
And just before the end of the first half, Tammy Abraham scored the second goal for Roma.
But the capital team did not maintain its primacy, despite hitting ten balls between the posts and the crossbar, and it conceded the equalizer in the 65th minute through a penalty kick by Mattia Aramo.
In the 74th minute, David Okereki struck a fatal blow to Wolves by scoring a third goal for Venice, who returned to the winning streak after the absence of 3 rounds.
Venice rose to 14th place, raising its score to 12 points, while Rome continued to be fifth, with a score of 19 points.
In the next round, on November 21, Venice will play against its host Bologna, while Roma will visit Genoa, who signed coach Andriy Shevchenko, the former Milan and Ukraine star.